EP 71: The TEDDY & CASCADE Studies
Discovering Genetic and Environmental Triggers for T1D, Plus Early Diagnosis Intervention Strategies
In this episode, Dr. Steve Edelman sits down with Michael Killian, Director of Clinical Services at Pacific Northwest Research Institute, to discuss two groundbreaking studies—TEDDY and Cascade—that have shaped our understanding of genetic and environmental triggers for type 1 diabetes. The TEDDY study, spanning over 20 years and involving nearly 8,800 participants, investigates why some genetically at-risk individuals develop type 1 diabetes while others do not. Cascade builds upon TEDDY’s findings, aiming to integrate early screening into standard healthcare and identify potential preventative interventions. Michael and Dr. Edelman break down the major findings of these studies, including the role of viruses, genetics, and immune responses, and what they mean for the future of type 1 diabetes prevention and treatment.
Very exciting to know that T1D may soon be preventable with early targeted screening and immune modulation
Agreed! 🙂
My non-T1d kids were in DAISY (precursor) and TEDDY, and I am happy to state neither has converted, even though at high risk. We supplemented with anti-inflammatory (fish oil) and D3 to support the immune system and looked at the epidemiology of populations who did not convert. See preventt1d.org and grassrootshealth.net/t1d. It is all open source and provides an alternative to very expensive MAB studies which have side effects and long term complications that are unknown. Most of the kids doing the MAB studies are doing all of the above – so what is working since those managing the MAB studies do not test for D3 or O3 levels, even though they know the families are supplementing.
I am happy that they are bringing up Coxsackie B – in a balanced way.
Dr. George Eisenbarth was a genius and recognized the importance of reducing inflammation – easy to measure with COX2 and CRP testing.
Thanks for sharing your story, Sonia!